Multi-stakeholder working offers many advantages over conventional approaches, with different perspectives helping to solve complex problems, which is particular important when change is potentially challenging or controversial. Multi-stakeholder working, however, comes with challenges, as bringing different sectoral cultures and priorities together can make decision-making time consuming and complicated. The guidance outlines six core steps and other considerations to form and deliver a multi-stakeholder group that works efficiently together and with the secretariat of a CoST member programme.